Revitalising the Single Batch Environment: A 'Quest' to Achieve Fairness and Efficiency

In the realm of computer systems, efficient utilisation of the CPU (Central Processing Unit) has always been a paramount concern. Researchers and engineers have long sought ways to optimise process execution on the CPU, leading to the emergence of CPU scheduling as a field of study. This research proposes a novel algorithm for batch processing that operates on a preemptive model, dynamically assigning priorities based on a robust ratio, employing a dynamic time slice, and utilising periodic sorting technique to achieve fairness. By engineering this responsive and fair model, the proposed algorithm strikes a delicate balance between efficiency and fairness, providing an optimised solution for batch scheduling while ensuring system responsiveness

Covalently Modulated and Transiently Visible Writing: Rational Association of Two Extremes of Water Wettabilities

Anticounterfeiting measures are of ever-increasing importance in society, e.g., for securing the authenticity of and the proof of origin for medical drugs. Here, an arms race of counterfeiters and valid manufacturers is taking place, resulting in the need of hard-to-forget, yet easy-to-read out marks. Anticounterfeiting measures based on micropatterns—while being attractive for their need in not widely available printing methods while still being easily read out with fairly common basic optical equipment—are often limited by being too easy to be destroyed by wear or handling. Here, nature-inspired wettability is rationally exploited for developing an unprecedented anticounterfeiting method, where hidden information can be only identified under direct exposures to an aqueous phase or mist and disappears again on air-drying the interface. A chemically reactive and hierarchically featured dip coating, capable of spatially selective covalent modification with primary amine containing small molecules, is developed for abrasion-tolerant patterning interfaces with two extremes of water wettabilities, i.e., superhydrophilicity and superhydrophobicity. Arbitrary handwriting with glucamine followed by chemical modification with octadecylamine, provided “invisible” text on the synthesized interface. The glucamine-treated region selectively becomes optically transparent and superhydrophilic due to rapid infiltration of the aqueous phase on exposure to liquid water or mist. The remaining interface remains opaque and superhydrophobic due to metastable entrapment of air. The hidden text became transiently and reversibly visible by the naked eye under exposure to liquid water/mist. Furthermore, microchannel-cantilever spotting (μCS) is adopted for demonstrating well-defined chemical patterning on the microscale. These patterns are at the same time highly resistant against wear and scratching because of the bulk functionalization, retaining the wetting properties (and thus pattern readout) even on serious abrasion. Such a simple synthesis of spatially controlled, direct, and covalently modulated wettability could be useful for various applied and fundamental contexts

Multiplexed Covalent Patterns on Double‐Reactive Porous Coating

We have conceptualized and demonstrated an approach based on the combination of hydrophobicity, a substrate‐independent dip coating as porous material with double residual chemical reactivities for implementing multiplexed, miniaturized and unclonable bulk‐infused patterns of different fluorophores following distinct reaction pathways. The embedded hydrophobicity (∼102°) restricted the unwanted spreading of beaded aqueous ink on the coating. The constructions of micropatterns on porous dip‐coating via ink‐jet printing or microchannel cantilever spotting offered orthogonal read‐out and remained readable even after removal of the exterior of the coating

Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients

The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). One of the isolates, T5, that was genotypically characterized as Leishmania tropica, caused Indian Kala-azar and was phenotypically Sb resistant (T5-LT-SSG-R), while the other two were Leishmania donovani, out of which one isolate, AG83, is antimony sensitive (AG83-LD-SSG-S) and the other isolate, T8, is Sb resistant (T8-LD-SSG-R). Our study showed that the Sb-resistant parasites, regardless of their genotype, showed significantly higher intracellular thiol compared with Sb-sensitive AG83-LD-SSG-S. Seemingly, T5-LT-SSG-R showed about 1.9-fold higher thiol content compared with T8-LD-SSG-R which essentially mirrored cell surface N-acetyl-D-galactosaminyl expression. Except TR, the expression of the remaining thiol-synthesizing genes was significantly higher in T8-LD-SSG-R and T5-LT-SSG-R than the sensitive one, and between the Sb-resistant parasites, the latter showed a significantly higher expression. Furthermore, the genes for Sb-reducing enzymes increased significantly in resistant parasites regardless of genotype compared with the sensitive one, and between two resistant parasites, there was hardly any difference in expression. Out of three antimony transporters, AQP1 was decreased with the concurrent increase in MRPA and PRP1 in resistant isolates when compared with the sensitive counterpart. Interestingly, no difference in expression of the above-mentioned transporters was noted between two Sb-resistant isolates. The enduring image that resonated from our study is that the genetically diverse Sb-resistant parasites showed enhanced thiol-synthesizing and antimony transporter gene expression than the sensitive counterpart to confer a resistant phenotype

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Molecular identification of an old clinical isolate of Indian Kala-azar

Molecular characterization is an important task for species identification of the isolates belonging to different Leishmania species. Clinical symptoms, tissue tropism, vector preference, reservoir and geographical distribution may act as distinguishing parameters but not always decisive. On the other hand, modern taxonomic tools employed to divulge characteristics of the genome or protein molecules of the parasite would be convincing and for Leishmania sp., they include nuclear and kDNA buoyant density, multi locus enzyme electrophoresis (MLEE), RAPD, RFLP or use of monoclonal antibodies etc. In the present study, we intend to establish the identification of an old clinical isolate of Indian Kala-azar, familiarly known as ‘UR6’ by MLEE, RAPD, RFLP and species specific monoclonal antibodies. UR6 has been isolated from a confirmed Kala-azar patient admitted in Calcutta School of Tropical Medicine, Kolkata in 1978. From then it is being regularly used for various scientific studies by the Leishmania Research Group of India and abroad. The isozyme profile of UR6 showed similar electrophoretic mobility that of WHO reference strain for Leishmania tropica, K27. Similar findings were obtained in the RAPD and RFLP assays. Screening with species specific monoclonal antibodies showed its strong reactivity towards L. tropica. The Jaccard’s Similarity Indices were calculated

Mechanical properties of Al7075 alloy with nano-ceramic oxide dispersion synthesized by mechanical milling and consolidated by equal channel angular pressing

An Al-alloy matrix composite with a dispersion of nano-TiO2 has been synthesized in powder form by mechanical milling of pre-alloyed Al7075 alloy and nano-TiO2 powder blend. XRD and TEM analyses of the milled powder confirm the particle/crystallite size in nanometer range. The composite powder was consolidated by equal channel angular pressing (ECAP) at ambient temperature and 473 K at a speed of 5 mm/min. Microstructural analysis of consolidated compacts of Al7075 alloy with nano-TiO2 dispersion was carried out using both scanning and transmission electron microscopy. The compacts prepared by ECAP possess reasonably good density (90% of theoretical density), excellent hardness (3.72 GPa/344 VHN) and high stiffness (Young's modulus of 92 GPa). Furthermore, the compacts consolidated by 4 ECAP passes at 473 K exhibit, beside the highest density, an extremely high compressive strength (approximate to 1.7 GPa). Conspicuously the above properties are independent of structural orientation as texture analysis shows almost random texture even after ECAP consolidation. (C) 2012 Elsevier B.V. All rights reserved

Mechanical properties of Al7075 alloy with nano-ceramic oxide dispersion synthesized by mechanical milling and consolidated by equal channel angular pressing

An Al-alloy matrix composite with a dispersion of nano-TiO2 has been sysnthesized in powder form b mechanical milling of pre-alloyed Al7075 alloy and nano-TiO2 powder blend. XRD and Tem analyses of the milled powder confirm the particle/crystallite size in nanometer range. The composite powder was consolidated by equal channel angular pressing (ECAP) at ambient temperature and 473 K at speed of 5mm/min. Microstructural analysis of consolidated compacts compacts of Al7075 alloy with nano-TiO2 dispers-ion was carried out using both scanning and transmission electron microscopy. The compacts prepared by ECAP possess reasonably good density (90% of theoretical density), excellent hardness (3.72 GPa/344 VHN) and high stiffness (Young’s modulus of 92 GPa). Furthermore, the compacts cons-olidated by 4 ECAP passes at 473 K exhibit, beside the highest density, an extremely high compressive stren-gth (1.7 GPa). Conspicuously the above properties are independent of structural orientation as texture analysis shows almost random texture even after ECAP consolidation